Author
University of Massachusetts Chan Medical School
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
Anusha Doddi, Pepper Dawes, Yingleong Chan, Elaine T. Lim
The paper develops an artificial neural network approach to integrate 2D/3D single-cell spatial RNA sequence data from virus-infected human cerebral organoids to study neurodegenerative disease mechanisms.
bioRxiv · Jun 11, 2026 · PreprintGenomics
Meagan N. Olson, Pepper Dawes, Liam F. Murray, Nathaniel Barton, Jonathan Sundstrom, Adrian R. Orszulak, Samantha M. Chigas, Khanh Tran, Aimee J. Aylward, Michele F. Caliandro, Sean‐Patrick Riechers, Khashayar Afshari, Qi Wang, Manuel G. Garber, Fiachra Humphries, , Elaine T. Lim
This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.
npj Dementia · Mar 9, 2026Peer-reviewedGenomics
Nathaniel Barton, Khanh V. Tran, Meagan N. Olson, Mugdha Deshpande, Irina Radu, Nimmy Francis, Mariana Kurban, Aurelie Martin-Puig, Molly Wilner, Adrian R. Orszulak, Samantha M. Chigas, Jonathan Sundstrom, Pepper Dawes, Liam F. Murray, Marcus Baiby, , Yingleong Chan
The paper screens cerebrospinal fluid from MS and non-MS patients using a multiplex peptide library to identify microbial and autoantigenic epitopes enriched in MS.
bioRxiv · Jul 5, 2024 · PreprintImmunology
Salome Funes, Jonathan Jung, Del Hayden Gadd, Michelle Mosqueda, Jianjun Zhong, Shankaracharya, Matthew Unger, Karly M. Stallworth, Debra Cameron, Melissa S. Rotunno, Pepper Dawes, Megan Fowler, Pamela J. Keagle, Justin A. McDonough, Sivakumar Boopathy, , Daryl A. Bosco
This study shows that ALS-linked PFN1 mutations impair vesicular degradation in iPSC-derived microglia by disrupting autophagy, which can be mitigated by Rapamycin.
Nature Communications · Mar 20, 2024Peer-reviewedNeuroscience
Molly Smullen, Meagan N. Olson, Julia M. Reichert, Pepper Dawes, Liam F. Murray, Christina E. Baer, Qi Wang, Benjamin P. Readhead, George McDonald Church, Elaine T. Lim, Yingleong Chan
The paper introduces a method to multiplex reprogram somatic cells into iPSCs and estimates donor contributions using pooled sequencing and SNPs, finding consistent reprogramming ability across donors.
Cell Reports Methods · Aug 31, 2023Peer-reviewedMolecular Biology
Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel Barton, Jivanna N. Mason, Yucheng Zhang, Aria Fernandez-Fontaine, George McDonald Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin P. Readhead
The paper investigates the association between mitochondrial variant MT:10398A>G and heteroplasmy in brain tissue and lymphoblastoid cell lines, identifying its role in mitochondrial function and disease phenotypes.
Scientific Reports · Jun 27, 2023Peer-reviewedGenomics
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J.C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, , George McDonald Church
The paper identifies cell type specific driver genes in autism-associated copy number loci using cerebral organoids and validates findings with CRISPR/Cas9-edited mosaic organoids.
Nature Communications · Jun 10, 2022Peer-reviewedGenomics