Author

Guang Yan

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:eQTL / molecular QTL mapping· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aria Fernandez-Fontaine· 1 shared Benjamin P. Readhead· 1 shared Christoph A. ThaissiD· 1 shared Daniela Min Jing Che Jin· 1 shared Diego MastroeniiD· 1 shared Elaine T. LimiD· 1 shared Emma Elizabeth FurthiD· 1 shared Emma Loeffler· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Aria Fernandez-Fontaine

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2 papers

Recent·Most cited

Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease

Naomi E. Butler Tjaden, Megan J. Liou, Sophie E. Sax, Nejia Lassoued, Meng Lou, Sabine Schneider, Katherine Beigel, Joshua D. Eisenberg, Emma Loeffler, Sierra E. Anderson, Guang Yan, Lev Litichevskiy, Lenka Dohnalová, Yixuan Zhu, Daniela Min Jing Che Jin, , Robert O. Heuckeroth

This study shows that diet can significantly affect survival in a mouse model of Hirschsprung disease by altering gut microbes, metabolites, and epithelial gene expression.

bioRxiv · Feb 10, 2025 · PreprintCell Biology

Modeling of mitochondrial genetic polymorphisms reveals induction of heteroplasmy by pleiotropic disease locus MT:10398A>G

Molly Smullen, Meagan N. Olson, Liam F. Murray, Madhusoodhanan Suresh, Guang Yan, Pepper Dawes, Nathaniel Barton, Jivanna N. Mason, Yucheng Zhang, Aria Fernandez-Fontaine, George McDonald Church, Diego Mastroeni, Qi Wang, Elaine T. Lim, Yingleong Chan, Benjamin P. Readhead

The paper investigates the association between mitochondrial variant MT:10398A>G and heteroplasmy in brain tissue and lymphoblastoid cell lines, identifying its role in mitochondrial function and disease phenotypes.

Scientific Reports · Jun 27, 2023Peer-reviewedGenomics