Peter C. Breen

The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the C. elegans intestine

This study shows that the TWK-26/KCNK3 potassium channel and FLR-4 protein kinase work together in C. elegans to regulate nutrient absorption and metabolic homeostasis.

Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

This study identifies a non-canonical role for Hedgehog signaling in maintaining lipid homeostasis through regulation of mTORC2 in C. elegans and mouse hepatocytes.

The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in C. elegans

This study identifies FBXL-5 as a negative regulator of vitellogenesis and lipid homeostasis in C. elegans, revealing its role in an SCF ubiquitin-ligase complex interacting with mTORC2 signaling.

Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans

The paper identifies a feedback loop where high cysteine levels activate HIF-1 to induce cdo-1, promoting cysteine degradation via an H2S signaling pathway in C. elegans.

Follicle stimulating hormone signaling opposes the DRL-1/FLR-4 MAP Kinases to balance p38-mediated growth and lipid homeostasis in C. elegans

The paper identifies a signaling network in C. elegans where DRL-1/FLR-4 MAP Kinases and opposing FLR-2/FSHR-1 signaling regulate growth and lipid homeostasis via p38/PMK-1 and PHA-4/FOXA.

Induction of RNA interference by C. elegans mitochondrial dysfunction via the DRH-1/RIG-I homologue RNA helicase and the EOL-1/RNA decapping enzyme

This study shows that mitochondrial dysfunction in C. elegans activates RNAi through a pathway similar to the mammalian RIG-I response, involving DRH-1 and EOL-1, and contributes to increased longevity.