Author

Peter Castaldi

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:benchmarking· 2 Research Focus:GWAS / association mapping· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Allison E. Ashley‐KochiD· 2 shared Álvaro AlonsoiD· 2 shared Amber Beitelshees· 2 shared April P. CarsoniD· 2 shared Brian S. CusteriD· 2 shared Carolyn Crandall· 2 shared Coleen DamcottiD· 2 shared Dawood DarbariD· 2 shared

Activity by Year

2015-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Allison E. Ashley‐KochORCID

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Author profile →

4 papers

Recent·Most cited

A framework for designing splice-junction experiments in deep 3' single-cell RNA sequencing

Aabida Saferali, Congjian Liu, Andrea S Vendrame, Kamakshi Bankoti, Jose Santos Cabrera, Yohannes Tesfaigzi, Peter Castaldi

The paper establishes a framework for designing splicing experiments in deep 3'-biased single-cell RNA sequencing by analyzing depth requirements and benchmarking against bulk RNA sequencing.

bioRxiv · Sep 28, 2026 · PreprintBioinformatics

Local ancestry-aware genome-wide meta-analysis uncovers novel genetic loci for sickle cell disease nephropathy

Melanie E. Garrett, Seyed Mehdi Nouraie, Roberto F. Machado, Victor R. Gordeuk, Mark T. Gladwin, Marilyn J. Telen, Allison E. Ashley‐Koch, Gonçalo Abecasis, François Aguet, Christine Albert, Laura Almasy, Álvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, , Mao Fu

This paper performs a local ancestry-aware GWAS on SCD cohorts to identify novel genetic loci associated with eGFR, uncovering regions linked to inflammation, ECM integrity, and other pathways relevant to SCD nephropathy.

Blood Advances · Aug 19, 2026Peer-reviewedGenetic & Genomic Medicine

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging

Woei‐Yuh Saw, Kangjin Kim, Yichen Huang, Jeong Hyun Yun, Xiaolong Ma, Jason Bacon, Yash Pershad, Daniel A Levy, George T. O’Connor, Eric Boerwinkle, R. Graham Barr, Stephen S. Rich, Jerome I. Rotter, April P. Carson, Laura M. Raffield, , Michael Rutledge DeBaun

This study investigates the association between mosaic loss of Y chromosome (mLOY) and lung function, emphysema, and epigenetic aging in men across multiple cohorts.

American Journal of Respiratory and Critical Care Medicine · Mar 19, 2026Peer-reviewedGenetic & Genomic Medicine

Buffet-Style Expression Factor-Adjusted Discovery Increases the Yield of Robust Expression Quantitative Trait Loci

Peter Castaldi, Ma’en Obeidat, Eitan Halper-Stromberg, Andrew Lamb, Margaret Parker, Robert Chase, Vincent Carey, Ruth Tal-Singer, Edwin Silverman, Don Sin, Peter D Paré, Craig Hersh

The paper shows that adjusting for expression factors reduces eQTL detection but proposes a buffet-style approach to balance power and accuracy.

bioRxiv · Oct 11, 2015 · PreprintGenomics