Disrupted cardiac bioenergetics linked to oxidized mitochondrial creatine kinase are rescued by the mitochondrial-targeting peptide SBT-20 in the D2.mdx model of Duchenne muscular dystrophy
Christopher G.R. Perry, Meghan C Hughes, Sofhia V Ramos, Aditya Brahmbhatt, Patrick C Turnbull, Nazari Polidovitch, Madison C Garibotti, Uwe Schlattner, Thomas J Hawke, Jeremy A Simpson, Peter H Backx
This paper investigates how mitochondrial bioenergetics are affected in D2.mdx mice and shows that SBT-20 can improve creatine-dependent bioenergetics by reducing oxidative stress.
bioRxiv · Feb 4, 2024 · PreprintPhysiology