Author

Peter Loppnau

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

C.H. ArrowsmithiD· 3 shared Dalia Baršytė-LovejoyiD· 3 shared Magdalena M. SzewczykiD· 3 shared A.M. EdwardsiD· 1 shared Aiymzhan Istayeva· 1 shared Alexandra AmaraliD· 1 shared Almagul Seitova· 1 shared Anika Hans· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

C.H. ArrowsmithORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Chemically induced USP21-KLHL12 association recruits USP21 to COPII assembly

Victoria Vu, Michael Kanaris, Esther Wolf, Sabrina Keller, Qi Liu, Conrad Veranso Simoben, Shabbir Ahmad, Viviane Reber, Magdalena M. Szewczyk, Peter Loppnau, Matthew E. R. Maitland, Ella C. Adamson, Paola Picotti, Derek Wilson, C.H. Arrowsmith, , Dalia Baršytė-Lovejoy

The paper shows that BAY-805 induces USP21-KLHL12 association, recruiting USP21 to COPII vesicles and impairing large cargo transport.

bioRxiv · Sep 17, 2026 · PreprintCell Biology

Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human Type II Transmembrane Serine Proteases

Bryan J. Fraser, Ryan P. Wilson, Jackie Lac, Olzhas Ilyassov, Almagul Seitova, Yanjun Li, Ashley Hutchinson, Peter Loppnau, Maria Kutera, Gregg B. Morin, François Bénard, C.H. Arrowsmith

This study shows HAI-2 inactivates TTSPs only after zymogen activation, revealing a novel mechanism for regulating these proteases and suggesting therapeutic applications.

Journal of Biological Chemistry · Aug 12, 2026Peer-reviewedBiochemistry

ABHD2 activity is not required for the non-genomic action of progesterone on human sperm

Madison Edwards, Alexandra Amaral, Eve M. Carter, Oliver Arnolds, Karen Vester, Anna Thrun, Edvard Wigren, Evert Homan, P. Ribera, Kirsty Bentley, Martin Haraldsson, Nmesoma Theo-Emegano, Peter Loppnau, Magdalena M. Szewczyk, Michelle Ada Cao, , Claudia Tredup

This study shows that ABHD2 activity is not required for progesterone-induced Ca2+ influx via CatSper and subsequent motility changes in human sperm.

Human Reproduction · May 29, 2026Peer-reviewedCell Biology

Direct-to-Biology Enables Rapid Identification of Potent FBXO22 Degraders

Carla Brown, Sarvatit Patel, Lihi Habaz, Magdalena M. Szewczyk, Aiymzhan Istayeva, Peter Loppnau, Stuart Green, Joseph S. Brown, C.H. Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar

The paper tests PROTACs targeting FBXO22 and finds no degradation of four targets but identifies potent FBXO22 homo-PROTACs and CRBN/VHL-mediated degraders.

bioRxiv · Mar 2, 2026 · PreprintCell Biology