PRDX6 Modulates Immune Checkpoint Inhibitor Response by Antagonizing Ferroptosis Induced By HDAC Inhibitors
Zeyu Liu, Jessy John, Nickolas A. Johnson, Priya Singh, Ziyi Wang, Gilson J. Sanchez, Dylan Simons, Jing Hong Wang, Xuedong Liu
This study identifies PRDX6 as a modulator of resistance to HDAC inhibitors and immune checkpoint therapies by suppressing ferroptosis and enhancing T-cell infiltration.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology