Dual function of DOT1L suppresses tumor intrinsic immunogenicity in hepatocellular carcinoma
Siyuan Xu, Ruijie Gong, Songchen Liu, Jianhua Wang, Yijie Shen, Chuxuan Peng, Qin Feng, Min Luo, Fei Lan, Jia Fan, Jiabin Cai, Xianjiang Lan
The paper identifies DOT1L as a suppressor of tumor intrinsic immunogenicity using CRISPR screens and shows its inhibition enhances immune response in mice.
Oncogene · Mar 30, 2026Peer-reviewedCell Biology