Wei Wei

This study identifies NF-κB-driven chromatin remodeling as a mechanism for drug-induced dedifferentiation in cancer, revealing its role in promoting drug-tolerant persister states.

This study uses spatial multi-omics to show cSCLC has a monoclonal origin, lineage plasticity, and distinct microenvironment niches, leading to a new diagnostic assay.

DTCFinder detects and characterizes disseminated and circulating tumor cells in liquid biopsies using single-cell RNA sequencing and machine learning without relying on labels or markers.

The paper investigates early signaling and transcriptional changes in melanoma cells under BRAF inhibitor treatment, identifying SFK activation as a compensatory mechanism and demonstrating its sensitivity to co-inhibition.

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

This study evaluates the castration model's utility in sex difference research using metabolome and transcriptome analyses in mice, showing it can feminize metabolic and transcriptomic profiles.