PARP1-mediated PARylation of SPRTN restrains its DNA-protein crosslink repair activity
Ayesha Rahman, Veronika Quevedo, Martin Garcia, Andrew Rhiner, Quincee Simonson, Estella Perez, Jaime Lopez-Mosqueda
This study shows PARP1-mediated PARylation of SPRTN limits its DNA-protein crosslink repair activity by reducing DNA binding and proteolytic function.
bioRxiv · Nov 6, 2026 · PreprintMolecular Biology