Bennett Van Houten

This study investigates how DNA Ligase IIIα ligates nicks in nucleosomes using biochemical assays, molecular dynamics, and cryo-EM, revealing position-dependent efficiency and structural constraints.

This study shows ATR kinase inhibitors cause mitochondrial fission and impair immune memory in CD8+ T cells during viral infection.

This study reveals how APE1 uses a dynamic search mechanism combining 1D and 3D diffusion to efficiently locate and repair AP-sites in DNA.

This study identifies PARP1's role in recruiting SPRTN to DPCs via PARylation, revealing a mechanism for DPC repair and degradation.

This study investigates how PARP1 binds to DNA breaks and chromatin, revealing that nucleosome unwrapping and allostery influence its affinity and binding dynamics.

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

This study uses single-molecule fluorescence to show TDG uses multiple diffusion modes to search for DNA lesions and how its structure affects nucleosome interactions.

This study identifies how CSB enhances SNM1A nuclease activity during ICL repair by interacting with its nuclease core and altering substrate conformation.

This study shows the Shu complex enhances RAD51 activity by stabilizing filaments and promoting RPA diffusion on ssDNA, with implications for cancer therapy.

This study compares single-molecule DNA binding dynamics of purified OGG1 and nuclear extracts using SMADNE, revealing differences in undamaged DNA binding and increased binding lifetime for a catalytically dead variant in nuclear extracts.

SMADNE characterizes DNA-binding protein dynamics using single-molecule analysis from nuclear extracts, revealing binding lifetimes, diffusion, and complex assembly kinetics.

This study shows that telomeric 8-oxoguanine induces premature senescence without telomere shortening by causing replication stress and dysfunction.