Molecular BiologybioRxivPreprint
PARP1-mediated PARylation of SPRTN restrains its DNA-protein crosslink repair activity
Ayesha Rahman, Veronika Quevedo, Martin Garcia…·Jaime Lopez-Mosqueda
This study shows PARP1-mediated PARylation of SPRTN limits its DNA-protein crosslink repair activity by reducing DNA binding and proteolytic function.
DOI 10.64898/2026.11.04.764412