WTAP-mediated epitranscriptomic program in alveolar macrophages confers prolonged protection against postinfluenza bacterial pneumonia
Yong Ge, Xinyi Hu, Zhen Li, Youxiang Cheng, R Chen, H Wu, Zekai Qian, Wenwen Song, Jingrong Huang, Yilin Zou, Nan Qi, A W Xu, Shaochun Yuan
The paper shows that reduced m6A in alveolar macrophages after influenza enhances trained immunity, improving antibacterial function and protecting against secondary infections.
bioRxiv · May 27, 2026 · PreprintImmunology