Shaochun Yuan

This study identifies a non-canonical pyroptosis pathway in cartilaginous fish involving GSDMA/B cleavage by LPS-activated caspase-1, revealing dual-fragment regulation and antimicrobial activity.

This study identifies IFN homologs in jawless vertebrates and demonstrates their antiviral function, tracing the evolutionary origin of IFN to basal chordates.

The paper shows that reduced m6A in alveolar macrophages after influenza enhances trained immunity, improving antibacterial function and protecting against secondary infections.

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.