Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance in a p53-dependent manner
A. Stigliani, R. Ialchina, J. Yao, D. Czaplinska, Y. Dai, H. Berg Andersen, R. Andersson, S. F. Pedersen, A. Sandelin
This study shows that pancreatic cancer organoids adapt to acidic environments, increasing drug resistance, and this effect is p53-dependent.
bioRxiv · Jan 2, 2023 · PreprintCancer Biology