J. Yao

Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites

This study shows that Lacticaseibacillus rhamnosus P118 enhances host resistance to Salmonella by promoting indole metabolites from gut microbes.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

AlphaFold2-Guided Functional Screens Reveal a Conserved Antioxidant Protein at ER Membranes

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasis

This study shows that acidic tumor environments enhance pancreatic cancer stem cell properties and metastasis in mice.

Incorporating Microbial Pilin-Based Nanowires into a Water-Stable Electronic Polymer Composite

This study creates a water-stable conductive composite using microbial pilin-based nanowires and demonstrates its use as a sensitive ammonia sensor with tunable response.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Translating Ethiopian potato seed networks: Identifying strategic intervention points for managing bacterial wilt and other diseases

This study identifies key locations and strategies to manage bacterial wilt spread in Ethiopia's potato seed systems through network analysis and risk assessment.

Perception of butenolides by Bacillus subtilis via the α/β-hydrolase RsbQ

This study identifies RsbQ in Bacillus subtilis as a butenolide hydrolase that mediates signaling responses to plant-derived butenolides, influencing growth and biofilm formation.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

On-Demand Expansion Fluorescence and Photoacoustic Microscopy (ExFLPAM)

This paper introduces ExFLPAM, a method that expands the capabilities of expansion microscopy by enabling on-demand fluorescent labeling and non-fluorescent imaging in live cells and tissues.

Lipid Bilayer Strengthens the Cooperative Network of Membrane Proteins

This study shows that lipid bilayers enhance membrane protein stability and their response to external stimuli by influencing hydrophobic thickness and amphiphile packing.

Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury

This study compares systemic and cardiac inflammatory responses to injury in mice and zebrafish using single-cell transcriptomics, revealing distinct monocyte/macrophage transcriptional clusters and divergent responses between species.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance in a p53-dependent manner

This study shows that pancreatic cancer organoids adapt to acidic environments, increasing drug resistance, and this effect is p53-dependent.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Microbial nanowires with genetically modified peptide ligands to sustainably fabricate electronic sensing devices

The paper demonstrates a genetic method to modify microbial nanowires with peptide ligands to enhance sensor response for specific analytes like ammonia and acetic acid.

DeepAIR: a deep-learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis

DeepAIR integrates sequence and 3D structure features of adaptive immune receptors to predict binding affinity and reactivity, outperforming existing methods on multiple tasks.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

Multi-Molecular Hyperspectral PRM-SRS Imaging

The paper introduces PRM-SRS imaging to visualize and identify multiple lipid species in cells and tissues with high chemical specificity and subcellular resolution.

Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

The Optimal Combination of Scanning Speed and Fiber-to-Stone Distance for Effective and Efficient Dusting during Holmium: YAG Laser Lithotripsy

This study identifies the optimal scanning speed and fiber-to-stone distance for maximizing dusting efficiency during Holmium: YAG laser lithotripsy by comparing photothermal ablation and cavitation effects.

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel

This study shows that tyrosine phosphorylation modulates TRPV2's chemical and thermal sensitivity in macrophages through JAK1 and PTPN1.

Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

Generating Electricity from Water Evaporation Through Microbial Biofilms

This paper demonstrates that engineered microbial biofilms can generate electricity from water evaporation, achieving power densities higher than non-biological materials.

Effects of short-term salinity exposure on haemolymph osmolality, gill morphology and Na+/K+ - ATPase activity in Solenaia oleivora

This study examines the physiological responses of Solenaia oleivora to short-term salinity exposure, showing changes in hemolymph osmolality, protein and amino acid concentrations, ion levels, and gill morphology.

STAYGREEN-mediated chlorophyll a catabolism is critical for photosystem stability upon heat stress in ryegrass

This study shows that suppressing Chl a catabolism in ryegrass reduces heat tolerance by disrupting photosystem stability, ROS balance, and chloroplast structure under moderate heat stress.

The framework of plant regeneration in duckweed (Lemna turonifera) comprises genetic transcript regulation and cyclohexane release

This study identifies genetic transcript regulation and cyclohexane release as factors enhancing duckweed regeneration through callus formation.

How drugs modulate the performance of the human heart

This study uses a multiphysics framework to show how drug concentrations affect heart rate, myofiber stretch, tissue relaxation, and cardiac output in the human heart.

Mapping Protein Numbers in Living Cells

The paper introduces a method to quantify protein numbers in live cells using fluorescence imaging and calibration curves, enabling 3D maps of protein density.

Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase

This study determines the structure of a group II intron RT template-switching complex, revealing mechanisms of template switching and non-templated addition, and their implications for RNA-seq and retroelement function.