R. Birsen

Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells

The paper identifies ferritinophagy as a therapeutic target in quiescent leukemic stem cells, showing that inhibiting NCOA4 reduces leukemia.

C/EBPα confers dependence to fatty acid anabolic pathways and vulnerability to lipid oxidative stress in FLT3-mutant leukemia

This study identifies C/EBPα's role in promoting lipid anabolism and vulnerability to lipid oxidative stress in FLT3-mutant AML through regulation of the FASN-SCD axis.