Q. Gu

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

This study analyzes the humoral immune response to SARS-CoV-2 XBB and JN.1 lineages, showing JN.1 elicits superior neutralization and highlights the need for JN.1-based vaccine boosters.

A Machine Learning Framework to Identify the Correlates of Disease Severity in Acute Arbovirus Infection

This study uses machine learning to identify key viral and host processes associated with varying severity in bluetongue virus infection in sheep.

Ferritinophagy is a Druggable Vulnerability of Quiescent Leukemic Stem Cells

The paper identifies ferritinophagy as a therapeutic target in quiescent leukemic stem cells, showing that inhibiting NCOA4 reduces leukemia.

CryoSTAR: Leveraging Structural Prior and Constraints for Cryo-EM Heterogeneous Reconstruction

CryoSTAR uses atomic models as constraints to improve cryo-EM reconstruction of conformational heterogeneity, showing better results across multiple datasets.

Trans-Lesion Synthesis and Mismatch Repair Pathway Crosstalk Defines Chemoresistance and Hypermutation Mechanisms in Glioblastoma

This study identifies RAD18's role in TMZ resistance and hypermutation in GBM by linking it to TLS and MMR pathways through CRISPR screening and mutation analysis.

Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV

This study shows that fever enhances the host's type-I IFN response to restrict MPXV replication.

Antigenicity and infectivity characterization of SARS-CoV-2 BA.2.86

This study characterizes the antigenic properties and infectivity of the SARS-CoV-2 BA.2.86 variant, finding it evades immune responses but has reduced infectivity compared to previous variants.

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

This study shows that convergent evolution of SARS-CoV-2 XBB lineages at RBD positions 455-456 synergistically enhances antibody evasion and ACE2 binding through epistatic interactions.

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

Zoonotic avian influenza viruses evade human BTN3A3 restriction

This study identifies BTN3A3 as a human restriction factor that inhibits avian influenza viruses but not human IAVs, with resistance linked to specific NP mutations.

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Omicron BA.2 specifically evades broad sarbecovirus neutralizing antibodies

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

Defining the Characteristics of Type I Interferon Stimulated Genes: Insight from Expression Data and Machine Learning

This paper identifies characteristics of type I interferon stimulated genes (ISGs) using expression data and machine learning, finding they are less conserved, have lower GC-content, and differ in network properties compared to non-ISGs.

Botrytis cinerea BcPTP1 is a late infection phase, cysteine rich protein cytotoxic effector

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Using Progressive Context Encoders for Anomaly Detection in Digital Pathology Images

A progressive context encoder trained only on normal skin whole slide images flags melanoma regions without manual tumor labels, reaching 89% pixel-level accuracy across 9 test slides.

A novel method for generating 3D constructs with branched vascular networks using multi-materials bioprinting and direct surgical anastomosis

This paper develops a method to create 3D vascularized tissues using bioprinting and surgical anastomosis, showing improved viability and functionality in liver-like constructs.

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of the induction of IFN-mediated innate immune defences

This study shows that elevated temperatures inhibit SARS-CoV-2 replication in respiratory epithelium without triggering IFN-mediated immune responses.

The therapeutic effects of intratumoral injection of IL12IL2GMCSF fusion protein on canine tumors

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.

A cucumber green mottle mosaic virus vector for virus-induced gene silencing in cucurbit plants

A CGMMV-based vector enables gene function studies in cucurbits, an extremely low efficiency species for genetic transformation.

Experimental infection characteristics of Bordetella pertussis via aerosol challenge on rhesus macaques

This study evaluates aerosol challenge of rhesus macaques with B. pertussis, showing similar infection characteristics to humans and supporting their use as a pertussis model.