Persistent Immunogenicity of Integrase Defective Lentiviral Vectors delivering membrane tethered Native-Like HIV-1 Envelope Trimers
A. Gallinaro, M. F. Pirillo, Y. Aldon, S. Cecchetti, Z. Michelini, A. Tinari, M. Borghi, A. Canitano, P. F. McKay, R. Bona, M. F. Vescio, F. Grasso, M. Blasi, S. Baroncelli, G. Scarlatti, , A. Cara
This study shows that IDLV vectors with membrane-tethered native-like HIV-1 Env trimers induce faster and longer-lasting anti-Env IgG responses in mice and macaques, with some animals developing neutralization activity against HIV-1.
bioRxiv · Oct 8, 2021Immunology