Author

A. Cara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:non-human primate· 1

Frequent Co-Authors

Z. Michelini· 3 shared A. Giovannelli· 2 shared C. Chiozzini· 2 shared C. LaBranche· 2 shared D. Negri· 2 shared F. Ferrantelli· 2 shared F. Manfredi· 2 shared M. Blasi· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Z. Michelini

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Staphylococcus aureus can use an alternative pathway to be internalized by osteoblasts in absence of β1 integrins

W. Mouton, L.-P. Tricou, A. Cara, S. Trouillet-Assant, D. Bouvard, F. Laurent, A. Diot, J. Josse

This study shows Staphylococcus aureus can enter osteoblasts without β1 integrins via vβ3/vβ5 integrins, revealing an alternative internalization pathway.

bioRxiv · Dec 13, 2023Cell Biology

Induction of SARS-CoV-2 N-specific CD8+ T cell immunity in lungs by engineered extracellular vesicles associates with strongly impaired viral replication

F. Manfredi, C. Chiozzini, F. Ferrantelli, P. Leone, k. Pugliese, M. Spada, A. Di Virgilio, A. Giovannelli, M. Valeri, A. Cara, Z. Michelini, M. Andreotti, M. Federico

This study shows that engineered extracellular vesicles inducing N-specific CD8+ T cells in lungs reduce SARS-CoV-2 replication in mice, with effects lasting up to three months post-vaccination.

bioRxiv · Jan 19, 2023 · PreprintImmunology

Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice.

F. Ferrantelli, C. Chiozzini, F. Manfredi, P. Leone, M. Spada, A. DiVirgilio, A. Giovannelli, M. Sanchez, A. Cara, Z. Michelini, M. Federico

This paper shows engineered extracellular vesicles induce strong N-specific CD8+ T cell immunity in mice, which protects against lethal SARS-CoV-2 infection.

bioRxiv · Jan 10, 2022Microbiology

Persistent Immunogenicity of Integrase Defective Lentiviral Vectors delivering membrane tethered Native-Like HIV-1 Envelope Trimers

A. Gallinaro, M. F. Pirillo, Y. Aldon, S. Cecchetti, Z. Michelini, A. Tinari, M. Borghi, A. Canitano, P. F. McKay, R. Bona, M. F. Vescio, F. Grasso, M. Blasi, S. Baroncelli, G. Scarlatti, , A. Cara

This study shows that IDLV vectors with membrane-tethered native-like HIV-1 Env trimers induce faster and longer-lasting anti-Env IgG responses in mice and macaques, with some animals developing neutralization activity against HIV-1.

bioRxiv · Oct 8, 2021Immunology

Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization

D. Lapuente, J. Fuchs, J. Willar, A. V. Antao, V. Everlein, N. Uhlig, L. Issmail, A. Schmidt, F. Oltmanns, A. S. Peter, S. Mueller-Schmucker, P. Irrgang, K. Fraedrich, A. Cara, M. Hoffmann, , M. Tenbusch

This study shows that intranasal adenoviral vector boosts after mRNA priming enhance mucosal immunity and protection against SARS-CoV-2 in mice.

bioRxiv · Aug 3, 2021Immunology

Immunogenicity, safety and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

M. Blasi, D. Negri, K. O. Saunders, E. J. Baker, H. Stadtler, C. LaBranche, B. Mildenberg, G. Morton, A. Ciarla, X. Shen, Y. Wang, W. Rountree, B. Balakumaran, S. Santra, B. F. Haynes, , M. E. Klotman

This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.

bioRxiv · Mar 6, 2020Immunology