RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
M. J. Girasol, M. Krasilnikova, C. A. Marques, J. D. Damasceno, C. Lapsley, L. Lemgruber, R. Burchmore, D. Beraldi, R. Carruthers, E. M. Briggs, R. McCulloch
This study shows RAD51 interacts with RNA-DNA hybrids and repairs DNA breaks at the transcribed VSG in T. brucei, linking RNA-DNA hybrids to antigenic variation.
bioRxiv · May 11, 2023Microbiology