R. Burchmore

Microbiome-derived metabolite effects on intestinal barrier integrity and immune cell response to infection

This study investigates how gut microbiome-derived metabolites affect intestinal barrier integrity and immune cell responses to infection at the cellular level.

Genomic diversity of novel strains of mammalian gut microbiome derived Clostridium XIVa strains is driven by mobile genetic element acquisition

The paper isolates and characterizes novel Clostridium XIVa strains from the murine gut, revealing genomic diversity driven by mobile genetic element acquisition and expanded biosynthetic potential.

Immunoprecipitation of RNA-DNA hybrid interacting proteins in Trypanosoma brucei reveals conserved and novel activities, including in host immune evasion by antigenic variation

The paper identifies 602 RNA-DNA hybrid interactors in Trypanosoma brucei using immunoprecipitation and mass spectrometry, revealing conserved and novel functions in DNA repair and immune evasion.

RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei

This study shows RAD51 interacts with RNA-DNA hybrids and repairs DNA breaks at the transcribed VSG in T. brucei, linking RNA-DNA hybrids to antigenic variation.

Microbiome-derived metabolites reproduce the mitochondrial dysfunction and decreased insulin sensitivity observed in type 2 diabetes

The paper identifies two microbiome-derived metabolites, 3M-4-TMAB and 4-TMAP, that induce mitochondrial dysfunction and reduced insulin sensitivity in human liver cells, linking gut microbiota to type 2 diabetes.

Essential roles for deubiquitination in Leishmania life cycle progression

This study identifies essential deubiquitinating enzymes (DUBs) in Leishmania life cycle progression and demonstrates their critical role in differentiation and intracellular survival.

Mapping the influence of the gut microbiota on small molecules in the brain through mass spectrometry imaging

This study uses mass spectrometry imaging to map microbial and host metabolites in the gut and brain of mice, finding altered metabolites in germ-free animals but not after antibiotic treatment.