Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patches
G. B. Armstrong, V. Shah, P. Sanches, M. Patel, R. Casey, C. J. Jamieson, G. A. Burley, W. J. Lewis, Z. Rattray
This study presents a framework for computationally screening mutations to modify antibody viscosity, showing that hydrophobic and electrostatic patches significantly affect viscosity, with positive charges causing the most increase.
bioRxiv · Mar 7, 2024 · PreprintBioengineering