M. Patel

CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.

Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer

The paper develops CXCR2-homing nanoparticles to specifically target PMN-MDSCs in PDAC, reducing arginase activity and enhancing T-cell activity without causing neutropenia.

A reference database of reptile images

The paper presents a standardized reference database of 14,000 reptile images from 20 collections, aiming to improve accessibility, interoperability, and comparability of reptile image data.

Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patches

This study presents a framework for computationally screening mutations to modify antibody viscosity, showing that hydrophobic and electrostatic patches significantly affect viscosity, with positive charges causing the most increase.

Helicobacter pylori cancer associated CagA protein drives intestinal metaplastic transition in human gastric organoids

This study shows that Helicobacter pylori's CagA protein induces intestinal metaplasia in human gastric organoids by activating STAT3 and increasing intestinal markers.

Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids

This study examines sex differences in FAHFA metabolism across tissues in mice, finding higher FAHFA levels in females in specific adipose depots and lower Adtrp expression, suggesting sex-dependent regulation of FAHFA metabolism.

A spatial human thymus cell atlas mapped to a continuous tissue axis

The paper maps the spatial organization of the human thymus across developmental stages using a multimodal atlas and identifies key cellular and molecular features of T cell development.

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity

This study identifies a circadian rhythm that regulates antiviral immunity in skin, showing that aging disrupts this rhythm and that circadian enhancers can restore antiviral defenses.

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

This paper identifies how HCMV targets ADAM17 to modulate surface proteins and immune pathways, revealing a novel viral immunomodulation strategy.

The Evolution of Democratic Peace in Animal Societies

This study applies evolutionary game theory to test the democratic peace hypothesis across animal societies, finding support for the idea that collective decision-making reduces intergroup conflict.

Cerebral malaria is regulated by host mediated changes in Plasmodium gene expression

The paper shows that Plasmodium ANKA parasites exhibit ECM-specific gene expression profiles that are activated only in susceptible hosts, indicating host influence on cerebral malaria outcomes.

Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

TLR4 signaling in presence of HIV-induced activation enhances programmed death ligand-1 expression on human plasmacytoid dendritic cells and modulates their function

This study shows that TLR4 signaling in HIV-infected individuals enhances PD-L1 expression and modulates pDC function, contributing to immune suppression.

Elevated HLA-E and NKG2A as a consequence of chronic immune activation defines resistance to M. bovis BCG immunotherapy in Non-Muscle-Invasive Bladder Cancer

The paper identifies elevated HLA-E and NKG2A as markers of resistance to BCG immunotherapy in NMIBC, linked to immune escape mechanisms.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits comparable B cell expansion, neutralizing antibodies and protection against Omicron

This study compares B cell responses and protection against Omicron after boosting vaccinated macaques with mRNA-1273 or mRNA-Omicron vaccines, finding comparable immunity and protection.

DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics

This study investigates how DRP1 mutations affect mitochondrial and peroxisomal dynamics, leading to metabolic dysfunction and structural abnormalities in EMPF1 patient fibroblasts.

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival niche

The paper creates a spatial multi-omics lung atlas identifying novel cell types and a survival niche for IgA-secreting plasma cells in submucosal glands.

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

This study evaluates how well antibodies from mRNA vaccines neutralize SARS-CoV-2 variants, finding that Omicron shows the most escape but booster doses maintain moderate neutralizing activity.

ZRC3308 monoclonal antibody cocktail shows protective efficacy in Syrian hamsters against SARS-CoV-2 infection

The paper develops a monoclonal antibody cocktail (ZRC-3308) effective against multiple SARS-CoV-2 variants in Syrian hamsters.

SARS-CoV-2-specific memory B cells can persist in the elderly despite loss of neutralising antibodies

Circulating class-switched spike and RBD-specific memory B cells can outlast detectable neutralising antibodies but are functionally constrained in the elderly.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

The balance between toxic versus nontoxic microRNAs determines platinum sensitivity in ovarian cancer

The paper shows that the ratio of toxic to nontoxic miRNAs in RISC predicts platinum sensitivity in ovarian cancer.

Exonic Disruption Facilitates Antiviral CRISPR-Cas9 Activity for Multistrain HIV-1 Elimination

This paper designs CRISPR-Cas9 guide RNAs targeting HIV-1 exons to reduce viral load in infected cells without off-target effects.

Identification of the toxic 6mer seed consensus in human cancer cells

The paper identifies GGGGGC as the most toxic 6mer seed in human cancer cells, confirming its mechanism through targeted gene disruption and reporter assays.

HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

The paper identifies Givinostat as a direct inhibitor of CGGBP1-DNA interaction, expanding its known mechanism beyond HDAC inhibition.

Energy deficit-independent stress response in the Frataxin-depleted heart: evidence that Integrated Stress Response can predominate over mTORC1 activation

This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 mutated acute myeloid leukemia

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

Accelerated single cell seeding in relapsed multiple myeloma

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking

This study investigates the role of vinculin in neutrophil adhesion, motility, and trafficking, finding that it partially affects adhesion and spreading but is dispensable for recruitment in vivo.

Teleost fish can accurately estimate distance travelled

This study shows teleost fish can accurately estimate distance travelled, suggesting similar neural mechanisms to terrestrial vertebrates, but finbeat counting is unreliable for aquatic odometry.