V. Shah

Design of PEG-based hydrogels as soft ionic conductors

This study designs PEG-based hydrogels with ionic conductivity by optimizing salt concentration, water content, and network structure to achieve desired mechanical and conductive properties.

A first insight into the developability of an IgG3: A combined computational and experimental approach

This study characterizes the developability of IgG3 mAbs using computational and experimental methods, finding poorer stability and higher viscosity compared to IgG1.

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.

Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patches

This study presents a framework for computationally screening mutations to modify antibody viscosity, showing that hydrophobic and electrostatic patches significantly affect viscosity, with positive charges causing the most increase.

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

Using energy to go downhill - a genoprotective role for ATPase activity in DNA topoisomerase II

This study shows that ATPase activity in type II topoisomerases prevents excessive DNA damage by regulating strand passage and cleavage.

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

This paper develops an MMP13-targeting siRNA conjugate that preferentially accumulates in arthritic joints, reducing disease markers and outperforming current treatments.

Amphiphilic particle-stabilized nanoliter droplet reactors with a multi-modal portable reader for distributive biomarker quantification

This paper develops a portable droplet reactor system for biomarker quantification in resource-limited settings, achieving low detection limits and comparable accuracy to ELISA.

Label free autofluorescence imaging permits comprehensive and simultaneous assignment of cell type identity and reveals the existence of airway secretory cell associated antigen passages (SAPs).

This paper introduces a label-free imaging technique using autofluorescence to identify airway cell types and discovers dynamic secretory cell-associated antigen passages.

Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure

This study shows Lenacapavir's antiviral effect comes from hyperstabilizing the HIV-1 capsid lattice, leading to loss of compartmentalization and capsid failure.

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 co-activation

This study identifies p300-mediated compensatory transcriptional programs that drive acute resistance to BET inhibitors in AML and suggests sequential BET- and p300-inhibition as a therapeutic strategy.

Counting of Enzymatically Amplified Affinity Reactions in Hydrogel Particle-Templated Drops

This paper presents a method to digitally count enzymatic reactions using hydrogel particle-templated drops, achieving femtomolar detection with standard equipment.

Rapid HIV-1 capsid interaction screening using fluorescence fluctuationspectroscopy

This paper develops a fluorescence fluctuation spectroscopy method to rapidly screen HIV-1 capsid interactors by detecting binding events in solution.

Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential

This study uses label-free imaging techniques to differentiate metastatic potential in breast cancer cells at single-cell resolution.

An Automated Addressable Microfluidics Device for Minimally-Invasive Manipulation of Cells and Fluids within Living Cultures

This paper introduces an automated microfluidics device for minimally invasive cell and fluid manipulation in living cultures, enabling better tissue engineering and monitoring.

Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes

This paper develops a fluorescence biosensor to quantify host protein interactions with HIV-1 capsid tubes in real-time using total internal reflection fluorescence microscopy.

Frequency-dependent response of Chromobacterium violaceum to sonic stimulation, and altered gene expression associated with enhanced violacein production at 300 Hz

This study shows that 300 Hz sonic stimulation increases violacein production in Chromobacterium violaceum by up-regulating genes involved in glucose metabolism and tryptophan synthesis.