Structural basis of Cdk7 activation by dual T-loop phosphorylation
R. Duster, K. Anand, S. C. Binder, M. Schmitz, K. Gatterdam, R. P. Fisher, M. Geyer
This study reports the crystal structure of fully activated Cdk7/Cyclin H/Mat1 complex with dual T-loop phosphorylations, revealing their distinct roles in kinase activity and substrate recognition.
bioRxiv · Feb 14, 2024 · PreprintBiochemistry