M. Geyer

Structural basis of Cdk7 activation by dual T-loop phosphorylation

This study reports the crystal structure of fully activated Cdk7/Cyclin H/Mat1 complex with dual T-loop phosphorylations, revealing their distinct roles in kinase activity and substrate recognition.

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb

This study identifies a direct interaction between actin and Cdk9 in P-TEFb, showing actin binds to actively elongating genes and inhibits polymerization during transcription.

hnRNPM and ELAVL1 control type I interferon induction by promoting IRF3 phosphorylation downstream of both cGAS and RIG-I

Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

This study uses nanobodies to reveal GSDMD pore formation mechanism and shows their therapeutic potential in preventing pyroptosis.

Pyroptosis inhibiting nanobodies block Gasdermin D pore formation

This study identifies nanobodies that inhibit GSDMD pore formation without affecting caspase cleavage, providing structural insights and potential drug design frameworks.

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

This study identifies p38 kinases as a central signaling hub for NLRP1 inflammasome activation in response to ribotoxic stress and virus infection.

SAVED by a toxin: Structure and function of the CRISPR Lon protease.

The paper reports the crystal structure of CRISPR-Lon, a protein that activates by binding cA4 and cleaves CRISPR-T to release a nuclease-like fragment.

The structure of HiSiaQM defines the architecture of tripartite ATP-independent periplasmic (TRAP) transporters

This paper presents the first cryo-EM structure of TRAP transporter membrane domains and identifies structural features that enable monomeric elevator architecture.

Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation

The paper determines the directionality of PYD filament growth by showing ASC elongates exclusively on the B-end of NLRP3 filaments, enabling a transition from NLRP3 nucleation to ASC elongation.

Cryo-EM structure of the NLRP3 decamer bound to the cytokine release inhibitory drug CRID3

The paper determines the cryo-EM structure of NLRP3 bound to CRID3, revealing how the inhibitor stabilizes the protein and provides insights for drug development.

Identification of Rf9 and unravelling the genetic complexity for controlling fertility restoration in hybrid wheat

The paper identifies a novel restorer-of-fertility locus, Rf9, on chromosome 6AS in wheat, associated with fertility restoration in hybrid wheat.

Global mapping of Salmonella enterica-host protein-protein interactions during infection

The paper maps Salmonella enterica effector-host protein-protein interactions during infection, identifying 421 novel interactions and demonstrating their roles in pathogenesis.

CDK13 Mutations Drive Melanoma via Accumulation of Prematurely Terminated Transcripts

This study identifies CDK13 mutations in melanoma, showing they lead to accumulation of truncated transcripts and poor survival, with a mechanism involving impaired ZC3H14 phosphorylation and PAXT complex recruitment.

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

This study shows CDK12 inhibition causes premature cleavage and polyadenylation in long DNA damage response genes, linked to their length and polyadenylation site distribution.