Sodium regulates PLC and IP3R-mediated calcium signalling in invasive breast cancer cells
A. D. James, K. P. Unthank, I. Jones, N. Sajjaboontawee, R. E. Sizer, S. Chawla, G. J. O. Evans, W. J. Brackenbury
This study shows that sodium depletion in breast cancer cells increases intracellular calcium via PLC and IP3R pathways, highlighting a link between Na+ and Ca2+ signaling in metastatic cells.
bioRxiv · Aug 10, 2022 · PreprintCancer Biology