S. Chawla

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.

Dynamic calcium-mediated stress response and recovery signatures in the fungal pathogen, Candida albicans

This study uses live-cell imaging to analyze calcium dynamics in Candida albicans under various stress conditions and identifies adaptation mechanisms.

Sodium regulates PLC and IP3R-mediated calcium signalling in invasive breast cancer cells

This study shows that sodium depletion in breast cancer cells increases intracellular calcium via PLC and IP3R pathways, highlighting a link between Na+ and Ca2+ signaling in metastatic cells.

Gene expression based inference of drug resistance in cancer

This study uses gene expression data and machine learning to predict drug resistance in cancer by analyzing pathway activity patterns rather than gene expression levels alone.

Microfluidic system-based time-course tracking of physical proximity between cells and its effect on gene expression for elucidating live single cancer-immune cell interactions

This study tracks physical proximity between NK and TNBC cells over time using a microfluidic system and links it to gene expression changes, revealing transcriptional memory in immune-cancer interactions.

Elevation of TRPV1 expression on T cells during experimental immunosuppression

This study shows TRPV1 expression increases during T cell immunosuppression and contributes to elevated intracellular calcium levels, similar to immune activation.

Inhibitory effect of eslicarbazepine acetate and S-licarbazepine on Nav1.5 channels

This study shows that eslicarbazepine acetate and S-licarbazepine inhibit Nav1.5 channels, potentially explaining prolonged PR intervals and suggesting possible anti-invasion effects in cancer.

Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo

This study shows metastatic breast cancer cells alter microglial morphology and electrical activity in the brain, contributing to seizures and cognitive issues.

Inferring causal pathways among three or more variables from steady-state correlations in a homeostatic system

The paper infers causal pathways among three or more variables in homeostatic systems using steady-state correlations and applies it to challenge the classical pathway in insulin resistance.

Foraging theory and the propensity to be obese: an alternative to thrift

The paper proposes a foraging optimization model to explain obesity, suggesting that reduced foraging risk in modern environments leads to increased adiposity through interactions between fear peptides and leptin.