Author

A. D. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:imaging· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

W. J. Brackenbury· 4 shared S. Chawla· 3 shared M. Nelson· 2 shared M. Yang· 2 shared N. Sajjaboontawee· 2 shared T. K. Leslie· 2 shared A. Holding· 1 shared A. J. Kennerley· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCancer Biology

W. J. Brackenbury

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

T. K. Leslie, A. Tripp, A. D. James, S. P. Fraser, M. Nelson, N. Sajjaboontawee, M. S. Toss, W. Fadhil, S. C. Salvage, M. Arias Garcia, M. Beykou, E. Rakha, V. Speirs, C. Bakal, G. Poulogiannis, , W. J. Brackenbury

This study identifies a Nav1.5-dependent feedback loop that links extracellular acidification to Na+ influx, promoting breast cancer metastasis.

bioRxiv · Jun 16, 2023Cancer Biology

Sodium regulates PLC and IP3R-mediated calcium signalling in invasive breast cancer cells

A. D. James, K. P. Unthank, I. Jones, N. Sajjaboontawee, R. E. Sizer, S. Chawla, G. J. O. Evans, W. J. Brackenbury

This study shows that sodium depletion in breast cancer cells increases intracellular calcium via PLC and IP3R pathways, highlighting a link between Na+ and Ca2+ signaling in metastatic cells.

bioRxiv · Aug 10, 2022 · PreprintCancer Biology

Sodium accumulation in breast cancer predicts malignancy and treatment response

A. D. James, T. K. Leslie, J. D. Kaggie, L. Wiggins, L. Patten, J. M. O'Duinn, S. Langer, M.-C. Labarthe, F. Riemer, G. Baxter, M. A. McLean, F. J. Gilbert, A. J. Kennerley, W. J. Brackenbury

This study uses 23Na MRI to show elevated sodium levels in breast tumors, which correlate with malignancy and treatment response, offering a non-invasive biomarker.

bioRxiv · Apr 14, 2021Cancer Biology

Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

M. Yang, A. D. James, R. Suman, R. Kasprowicz, M. Nelson, P. O'Toole, W. J. Brackenbury

The paper shows Nav1.5 channels depolarize the membrane potential, increasing Rac1 activation and promoting cell migration.

bioRxiv · Aug 9, 2019Cell Biology

Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo

A. Simon, M. Yang, J. L. Marrison, A. D. James, P. J. O'Toole, P. M. Kaye, M. A. Whittington, S. Chawla, W. Brackenbury

This study shows metastatic breast cancer cells alter microglial morphology and electrical activity in the brain, contributing to seizures and cognitive issues.

bioRxiv · May 14, 2019Cancer Biology