Prion-like α-synuclein pathology in the brains of infants: Krabbe disease as a novel seed-competent α-synucleinopathy
C. Hatton, S. S. Ghanem, D. Koss, I. Y. Abdi, E. Gibbons, R. Guerreiro, J. Bras, International DLB Genetics Consortium, L. Walker, E. Gelpi, W. Heywood, T. F. Outeiro, J. Attems, B. McFarland, R. Forsyth, , D. Erskine
This study shows that α-synuclein in Krabbe disease brains can seed fibrillar aggregates similar to Lewy body diseases, indicating prion-like properties in infants.
bioRxiv · Oct 12, 2021 · PreprintPathology