L. Walker

Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats

This study shows that thermoneutral housing causes perivascular adipose tissue remodeling in rats, leading to sex-dependent impairments in vasoreactivity and mitochondrial function.

Evolution of sex differences in cooperation: the role of trade-offs with dispersal

This study tests hypotheses about sex differences in cooperation by analyzing dispersal patterns in white-browed sparrow weavers, finding support for the Dispersal trade-off hypothesis over the Philopatry hypothesis.

Fecal pH and redox as functional markers in the premature infant gut microbiome

This study identifies fecal pH and redox as potential biomarkers for metabolic state in preterm infants by linking them to microbiome composition and clinical outcomes.

ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer

This study shows ST3Gal1 promotes immune evasion in prostate cancer by synthesizing Siglec ligands, and its activity can be modulated by enzalutamide.

A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae

The paper maps LuxO and HapR genome-wide in V. cholerae, showing their interaction with CRP at shared sites to integrate quorum sensing and cAMP signalling for gene regulation.

Interactive Bioacoustic Playback as a Tool for Detecting and Exploring Nonhuman Intelligence: Conversing with an Alaskan Humpback Whale

The paper describes an acoustic interaction between humans and a humpback whale, showing the whale's intentional participation in different phases of a playback experiment.

Cell-type specific transcriptional networks in root xylem adjacent cell layers

The paper identifies cell-type specific transcriptional networks in Arabidopsis root xylem-adjacent layers using promoter tagging and chromatin analysis, revealing ZAT6's role in regulating Na+ accumulation.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

Cellular and gene expression patterns associated with root bifurcation in Selaginella

This study identifies symmetric cell division and conserved genetic modules in root bifurcation of Selaginella moellendorffii.

Prion-like α-synuclein pathology in the brains of infants: Krabbe disease as a novel seed-competent α-synucleinopathy

This study shows that α-synuclein in Krabbe disease brains can seed fibrillar aggregates similar to Lewy body diseases, indicating prion-like properties in infants.

Multimodal Single-Cell Characterization of the Human Granulocyte Lineage

This study uses multi-modal CITE-seq to accurately characterize human granulocytes, showing higher transcript detection with BD Rhapsody compared to 10X Genomics.

A combination of RBD and NTD neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

This paper identifies NTD-targeting neutralizing antibodies and shows that combining RBD and NTD antibodies reduces the emergence of neutralization-escape mutants.

Efficient discovery of potently neutralizing SARS-CoV-2 antibodies using LIBRA-seq with ligand blocking

This study demonstrates that integrating ligand blocking into LIBRA-seq improves the efficiency of identifying potent SARS-CoV-2 neutralizing antibodies.

CITEseq analysis of non-small-cell lung cancer lesions reveals an axis of immune cell activation associated with tumor antigen load and TP53 mutations

The paper analyzes CITEseq data from NSCLC lesions to identify an immune cell activation module linked to tumor antigen load and TP53 mutations.

Impacts of radiation on the bacterial and fungal microbiome of small mammals in the Chernobyl Exclusion Zone

The paper examines how radiation affects the gut and fecal microbiomes of small mammals in the Chernobyl Exclusion Zone, finding species-specific responses and differences between gut and fecal samples.

The quorum sensing transcription factor AphA directly regulates natural competence in Vibrio cholerae

This paper shows AphA represses natural competence in V. cholerae by directly repressing tfoX, while HapR activates it, revealing dual regulation of DNA uptake.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy