Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions
B. Layish, R. Goli, H. Flick, S.-W. Huang, R. Zhang, M. Kvaratskhelia, M. Kane
This study shows that MX2 antiviral activity depends on CypA-CA interactions and GTPase function, with loss of GTPase activity altering Nup requirements for viral restriction.
bioRxiv · Nov 16, 2023Microbiology