R. Zhang

Genome-wide screen identifies novel factors for surface protein cross-wall trafficking and cell envelope homeostasis in Staphylococcus aureus

This study identifies novel factors regulating YSIRK protein cross-wall trafficking and cell envelope homeostasis in S. aureus through a transposon mutant screen and phenotypic analysis.

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

Spatiotemporal regulation of Pseudorabies Virus Thymidine kinase UL23 by post-translational modification

This study investigates SUMO modification of PRV UL23 and shows it affects subcellular localization but not stability.

A Real-time Multi-Subject Three Dimensional Pose Tracking System for Analyzing Social Behaviors of Non-human Primates

This paper introduces MarmoPose, a real-time 3D pose tracking system for non-human primates, enabling analysis of social behaviors and closed-loop experiments in marmosets.

Unraveling the Role of Urea Hydrolysis in Salt Stress Response during Seed Germination and Seedling Growth in Arabidopsis thaliana

This study shows that salt stress increases urea hydrolysis in Arabidopsis thaliana, raising cytoplasmic pH and inhibiting seed germination and seedling growth, challenging the traditional view of ammonium toxicity as the main cause.

PathEX: Make Good Choice for Whole Slide Image Extraction

PathEX improves tile image extraction from whole slide images by adjusting IoT and BoT parameters to focus on annotated regions' boundaries and exclude blank tiles.

YAP promotes chromosomal instability by transcriptionally activating AJUBA through its super enhancer in breast cancer

This study identifies YAP's role in promoting chromosomal instability in breast cancer by activating AJUBA through its super enhancer, leading to AURKA activation and aberrant mitosis.

Accumulation of Oncogenic Mutations During Progression from Healthy Tissue to Cancer

The paper models mutation accumulation during cancer progression, analyzing premalignant population sizes and waiting times to malignancy in colorectal cancer and chronic myeloid leukemia.

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits

The paper discovers synthetic antibodies specific to RGD-binding integrins and identifies their subunit pairing preferences.

A multi-institutional study to investigate the sparing effect after whole brain electron FLASH in mice: Reproducibility and temporal evolution of functional, electrophysiological, and neurogenic endpoints

This study evaluates the reproducibility and temporal evolution of FLASH and CONV irradiation effects on mice, showing FLASH sparing at late but not early time points.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

Rim4 is a Meiotic Thermal Sensor and Drives Biogenesis of Stress Granules

This paper identifies Rim4 as a meiotic thermal sensor that forms reversible condensates triggered by heat, promoting stress granule assembly and protecting meiotic processes from thermal stress.

Morphological deficits of glial cells in a transgenic mouse model for developmental stuttering

The paper examines glial cell morphology in a Gnptab-mutant mouse model linked to stuttering, finding altered astrocyte and microglia processes in vocal production circuits.

Profiling cellular heterogeneity and fructose transporter expression in the rat nephron by integrating single-cell and microdissected tubule segment transcriptomes

The paper integrates single-cell and microdissected transcriptomes to show fructose transporter expression varies across rat nephron segments, with S3 being the primary site of fructose reabsorption.

Effects of greening-induced warming and cooling on tree phenology in temperate and boreal forests

This study shows forest greening alters tree phenology by causing earlier spring and autumn events through seasonal biophysical warming and cooling effects.

Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

Molecular Regulation of Invasive Protrusion Formation at the Mammalian Fusogenic Synapse

The paper identifies the spatiotemporal coordination of WAVE and N-WASP with actin-bundling proteins in invasive protrusion formation at the mammalian fusogenic synapse.

Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids

The paper shows that IncX4 plasmids with pir-1 have higher mcr-1 expression and fitness burden but lower invasion rates compared to pir-2 plasmids, explaining why mcr-1 is absent from pir-2 plasmids.

Tagging of water masses with covariance of trace metals and prokaryotic taxa in the Southern Ocean

The paper examines links between prokaryotic taxa and trace metals in Southern Ocean water masses using PLSR analysis.

Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions

This study shows that MX2 antiviral activity depends on CypA-CA interactions and GTPase function, with loss of GTPase activity altering Nup requirements for viral restriction.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect

This study investigates how anesthetic oxygen use and sex affect the FLASH sparing effect in mice, finding that 100% oxygen reduces FLASH sparing and females show greater ulceration than males under oxygen.

Identification and functional analysis of eRNA markers for hepatocellular carcinoma based on high-throughput data

This study identifies three eRNA biomarkers for hepatocellular carcinoma (HCC) and shows their involvement in cancer progression, prognosis, and potential as therapeutic targets.

A bioactive peptide from the pearl has dual roles in resisting SARS-CoV-2 infection and its complications

This study identifies a bioactive peptide from a pearl oyster that inhibits SARS-CoV-2 infection and enhances ACE2 activity to treat related complications.

Membrane Lipids Augment Cell Envelope Stress Signaling and Resistance to Antibiotics and Antimicrobial Peptides in Enterococcus faecalis

This study identifies the MadRS system and its operon madEFG as mediators of resistance to antimicrobial peptides and antibiotics in Enterococcus faecalis, linking membrane lipid changes to stress response and virulence.

Gap-free X and Y chromosomes of Salix arbutifolia reveal an evolutionary change from male to female heterogamety in willows, without a change in the sex-determining region

The paper assembles gap-free X and Y chromosomes of Salix arbutifolia, revealing evolutionary changes in sex determination from XY to ZW without altering the sex-determining region.

Efficacy of the first bioactive peptide from the pearl

The paper identifies a novel ACE-inhibitory peptide from pearl matrix and demonstrates its potential as an antihypertensive agent.

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

This study shows GABRD promotes breast cancer progression by regulating the cell cycle through CDK1 interaction.

Bio-inspired mineralization collagen induce fibrocartilage regeneration after tendon-bone injury by activating Gli1+Dkk3+ progenitor cells

This study develops a bio-inspired hydrogel that promotes tendon-bone interface regeneration by activating Gli1+Dkk3+ progenitor cells, achieving 68% mechanical recovery.

Potassium-mediated bacterial chemotactic response

This study investigates how Escherichia coli uses potassium concentration changes for chemotaxis, revealing distinct responses from two chemoreceptors and linking potassium sensing to intracellular pH changes.