The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model
R. Knaap, R. Fernandez-Delgado, T. J. Dalebout, N. Oreshkova, P. J. Bredenbeek, L. Enjuanes, I. Sola, E. J. Snijder, M. Kikkert
This study shows that disrupting the deubiquitinating activity of MERS-CoV PLpro enhances innate immune responses and reduces virulence in mice.
bioRxiv · Aug 29, 2019 · PreprintMicrobiology