L. Enjuanes

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

The paper analyzes SARS-CoV-2 mutant spectra from diagnostic samples and finds higher point mutation complexity in isolates from patients with mild disease compared to moderate or severe disease.

This paper develops a reverse genetics system for bovine torovirus using a full-length infectious cDNA clone, demonstrating the effects of genetic manipulations on viral growth and gene stability.

This study isolates two cross-reactive monoclonal antibodies against multiple Betacoronaviruses, identifying a conserved vulnerable site on the spike protein.

This study shows that currently available IVIG products neutralize SARS-CoV-2 and SARS-CoV in cell cultures but not MERS-CoV.

This study shows that disrupting the deubiquitinating activity of MERS-CoV PLpro enhances innate immune responses and reduces virulence in mice.