Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death
R. L. Ang, J. P. Sundberg, S.-C. Sun, V. L. Gillespie, P. Heeger, H. Xiong, S. A. Lira, A. T. Ting
This study shows that immune dysregulation in SHARPIN-deficient mice depends on CYLD-mediated cell death, with CYLD inhibition leading to TNF-induced cell death and multi-organ inflammation.
bioRxiv · Jan 27, 2020Immunology