Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
C. Chattopadhyay, J. Roszik, R. Bhattacharya, M. Alauddin, I. Mahmud, S. Yadugiri, M. M. Ali, F. S. Khan, V. V. Prabhu, P. Lorenzi, E. Burton, R. R. Morey, R. Lazcano, M. A. Davies, S. P. Patel, E. A. Grimm
The paper tests imipridones in a mouse model of uveal melanoma, finding they reduce tumor growth and improve survival by targeting oxidative phosphorylation.
bioRxiv · Jan 12, 2024Cancer Biology