Author

J. Roszik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

C. Chattopadhyay· 2 shared E. A. Grimm· 2 shared R. Bhattacharya· 2 shared A. A. Singhi· 1 shared A. Aggarwal· 1 shared A. Mahendra· 1 shared A. Maitra· 1 shared A. N. Hosein· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

C. Chattopadhyay

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Author profile →

4 papers

Recent·Most cited

Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma

C. Chattopadhyay, J. Roszik, R. Bhattacharya, M. Alauddin, I. Mahmud, S. Yadugiri, M. M. Ali, F. S. Khan, V. V. Prabhu, P. Lorenzi, E. Burton, R. R. Morey, R. Lazcano, M. A. Davies, S. P. Patel, E. A. Grimm

The paper tests imipridones in a mouse model of uveal melanoma, finding they reduce tumor growth and improve survival by targeting oxidative phosphorylation.

bioRxiv · Jan 12, 2024Cancer Biology

Targeting IRS-1/2 in uveal melanoma inhibits in vitro cell growth, survival and migration, and in vivo tumor growth.

C. Chattopadhyay, R. Bhattacharya, J. Roszik, F. Khan, G. A. Wells, H. Villanueva, Y. Qin, R. Bhattacharya, S. Patel, E. A. Grimm

This study shows that NT157, an IRS-1/2 inhibitor, reduces uveal melanoma cell growth, survival, migration, and tumor growth in vivo.

bioRxiv · Oct 26, 2022 · PreprintCell Biology

Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

A. N. Hosein, G. Dangol, T. Okumura, J. Roszik, K. Rajapakshe, M. Siemann, B. Ghosh, M. E. Monberg, P. A. Guerrero, M. Zaid, A. A. Singhi, C. L. Haymaker, H. Clevers, S. M. Woermann, L. Abou-Elkacem, A. Maitra

This study shows that loss of Rnf43 accelerates Kras-driven pancreatic cancer and alters the tumor immune microenvironment by increasing lymphocytes and immune checkpoint expression.

bioRxiv · May 29, 2021Cancer Biology

Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling

A. Mahendra, X. Yang, S. Abnouf, D. Park, S. Soomro, J. R. T. Adolacion, J. Roszik, C. Coarfa, G. Romain, K. Wanzeck, S. L. Bridges, A. Aggarwal, P. Qiu, S. K. Agarwal, C. Mohan, N. Varadarajan

This study identifies novel roles of autoreactive B cells in RA through transcriptome profiling, revealing potential therapeutic targets and mechanisms.

bioRxiv · Jun 1, 2017Immunology