Author

A. Lazar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Terranova· 2 shared E. Keung· 2 shared K. Rai· 2 shared M. Maitituoheti· 2 shared M. Tang· 2 shared S. Jiang· 2 shared S. Sarkar· 2 shared A. Bernat· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

C. Terranova

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade

J. Moore, J. Gkantalis, I. Guix, W. Chou, K. Yuen, A. Lazar, M. H. Spitzer, A. Combes, M. H. Barcellos-Hoff

This study identifies a biomarker, {beta}Alt, that predicts immune checkpoint blockade response in cold tumors by integrating TGF{beta} signaling, DNA repair, and immune context signatures.

bioRxiv · Mar 6, 2024 · PreprintCancer Biology

Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance

M. Maitituoheti, A. Shi, M. Tang, L.-L. Ho, C. Terranova, K. Galani, E. Keung, C. Creasy, M. Wu, J. Chen, N. Chen, A. Singh, A. Chaudhri, N. Anvar, G. Tarantino, , K. Rai

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

The spatial landscape of Cancer Hallmarks reveals patterns of tumor ecology

M. Sibai, S. Cervilla, D. Grases, E. Musulen, R. Lazcano, C.-K. Mo, V. Davalos, A. Fortian, M. Romeo, A. Bernat, C. Tokheim, E. Grande, F. Real, J. Barretina, A. Lazar, , E. Porta-Pardo

The paper uses spatial transcriptomics to analyze Cancer Hallmarks in 63 tumors, revealing spatial patterns of hallmark activity and interdependencies between cancer and tumor microenvironment.

bioRxiv · Jun 18, 2022Cancer Biology

Landscape scale ecology of Tetracladium spp. fungal root endophytes

A. Lazar, R. M. Mushinski, G. D. Bending

The paper examines Tetracladium spp. fungal communities in oilseed rape soils, finding they are diverse and correlate with crop yield and soil factors.

bioRxiv · May 26, 2022Microbiology

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

M. Maitituoheti, E. Keung, M. Tang, L. Yan, H. Alam, G. Han, A. Raman, C. Terranova, S. Sarkar, E. Orouji, S. Amin, S. Sharma, M. Williams, N. S. Samant, M. Dhamdhere, , K. Rai

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

bioRxiv · Dec 27, 2018Cancer Biology