SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes
A. Yildirim, S. Mozaffari-Jovin, A.-K. Wallisch, J. Ries, S. Ludwig, H. Urlaub, R. Luehrmann, U. Wolfrum
This study identifies SANS as a regulator of pre-mRNA splicing by facilitating the transfer of tri-snRNP complexes between Cajal bodies and nuclear speckles, linking it to Usher syndrome pathophysiology.
bioRxiv · Nov 11, 2020Cell Biology