S. Ludwig

Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA

This paper shows that inhibiting glycolysis with 2-DG reduces influenza A virus replication by impairing the viral polymerase's transition from transcription to replication.

Bioorthogonally Cross-Linked Hyaluronan-Laminin Hydrogels for 3D Neuronal Cell Culture and Biofabrication

This paper introduces a hydrogel system for 3D neuronal cell culture using bioorthogonal chemistry to functionalize hyaluronan and poly(ethylene glycol) with laminin 521, showing improved cell viability and differentiation.

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

Phosphorylation of JIP4 at S730 presents anti-viral properties against influenza A virus infection

This study identifies phosphorylation of JIP4 at S730 as an anti-viral mechanism against influenza A virus by inhibiting viral polymerase activity.

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexes

This study identifies SANS as a regulator of pre-mRNA splicing by facilitating the transfer of tri-snRNP complexes between Cajal bodies and nuclear speckles, linking it to Usher syndrome pathophysiology.

Mechanism of negative regulation of NF-κB by N4BP1

This study identifies N4BP1 as an inhibitor of NF-κB activation by interacting with NEMO, and shows that caspase 8 cleavage inactivates N4BP1 during TRIF-dependent signaling.

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS-CoV-2 infection in vitro

This study evaluates the antiviral effects of combining remdesivir with repurposed drugs fluoxetine and itraconazole, showing >90% inhibition of SARS-CoV-2 particle production in vitro.

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

This study shows SARS-CoV-2 adapts to Vero E6 cells by losing the furin cleavage motif in spike protein, but retains wildtype sequences, enabling reverse adaptation when passaged on human lung cells.

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine

This study identifies fluoxetine and other FIASMAs as inhibitors of SARS-CoV-2 entry by targeting endolysosomal acidification and cholesterol accumulation.

Evaluation of Field Sampling Techniques for Environmental Microbial Exposure: Assessing Efficacy and Feasibility

The paper compares two microbial sampling techniques in schools, finding electrostatic cloths more effective than swabs for quantifying Staphylococcus burden.

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

The paper identifies potent SARS-CoV-2 neutralizing antibodies from pre-pandemic human donors that bind the RBD-ACE2 interface, showing high neutralization efficacy in vitro.

Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7.

This study creates a humanized mouse model with enhanced T cell differentiation by expressing human IL-7 in specific tissues, leading to increased functional T cells without lymphoproliferation.

Microbial Food Safety in the Maryland Direct-to-Consumer Poultry Supply Chain

This study compares microbial safety in Maryland direct-to-consumer poultry products to conventional supply chains, finding lower rates of antimicrobial-resistant pathogens.