Biosynthesis of an Anti-Addiction Agent from the Iboga Plant
S. E. O'Connor, S. Farrow, O. M. Kamileen, L. Caputi, K. Bussey, J. Mundy, R. McAtee, C. Stephenson
The paper reports the biosynthesis of (-)-voacangine and its conversion to (-)-ibogaine, revealing enantioselectivity in enzymatic Diels-Alder reactions for anti-addiction alkaloids.
bioRxiv · May 26, 2019Biochemistry