TRIAC disrupts cerebral thyroid hormone action via a negative feedback loop and heterogenous distribution among organs
I. Yamauchi, T. Hakata, Y. Ueda, T. Sugawa, R. Omagari, Y. Teramoto, S. F. Nakayama, D. Nakajima, T. Kubo, N. Inagaki
This study shows TRIAC disrupts cerebral thyroid hormone action by reducing circulating TH levels and being poorly distributed to the brain, while compensating in peripheral tissues.
bioRxiv · Aug 12, 2022Ecology