Y. Ueda

Phosphodiesterase 3 inhibitors boost bone outgrowth

This study shows that PDE3 inhibitors enhance bone growth by increasing Ca2+ influx through TRPM7 channels in chondrocytes, suggesting potential repositioning for short stature syndromes.

A hemoperfusion column selectively adsorbs LAP+ lymphocytes to improve anti-tumor immunity and survival of tumor-bearing rats

The paper develops a hemoperfusion column that removes LAP+ lymphocytes, enhancing anti-tumor immunity and survival in tumor-bearing rats.

Comparative root transcriptome analysis suggests down-regulation of nitrogen assimilation in DJ123, a highly phosphorus-efficient rice genotype

The paper compares root transcriptomes of two rice genotypes under phosphorus conditions to identify molecular mechanisms underlying phosphorus-use efficiency.

High-throughput screening for Cushing's disease: therapeutic potential of thiostrepton via cell cycle regulation

This study identifies thiostrepton as a potential therapy for Cushing's disease by inducing cell cycle arrest in PitNETs through mechanisms independent of FOXM1.

Mutual interplay of actin meshwork and stress fibers in cellular adaptive response: Insights from percolation dynamics

The paper uses percolation theory to show how actin filaments form stress fibers through stochastic interactions, with assembly influenced by preexisting actin meshwork and disassembly independent of it.

Transcriptomic Landscape of Hyperthyroidism in Mice Overexpressing Thyroid Stimulating Hormone

This study analyzes the transcriptome of hyperthyroid mice overexpressing TSH, identifying novel genes and pathways associated with goiter development and thyroid hormone secretion.

TRIAC disrupts cerebral thyroid hormone action via a negative feedback loop and heterogenous distribution among organs

This study shows TRIAC disrupts cerebral thyroid hormone action by reducing circulating TH levels and being poorly distributed to the brain, while compensating in peripheral tissues.

Emergence of multiple set-points of cellular homeostatic tension

The paper investigates how stress fibers in cells can exhibit multiple stable tension levels, explaining the emergence of different homeostatic set-points under varying mechanical conditions.

A model for determining the length distribution of actin filaments in cells

The paper develops a theoretical model to determine the length distribution of actin filaments that maintains cellular tensional homeostasis by optimizing entropic quantities under constraints of actin molecules and tension.

C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

This study identifies a signaling pathway involving CNP, NPR2, PKG, BK channels, and TRPM7 that facilitates Ca2+ entry in growth plate chondrocytes to stimulate bone growth.

Human iPSC-derived mesodermal progenitor cells preserve their vasculogenesis potential after extrusion and form hierarchically organized blood vessels

This study shows that human iPSC-derived mesodermal progenitor cells can form hierarchical blood vessels after extrusion in bioprinting, mimicking embryonic vasculogenesis.

Novel Thyroid-Specific Autoantibodies in Patients with Immune-Related Adverse Events Involving the Thyroid Gland

This study identifies novel thyroid-specific autoantibodies in patients with immune-related adverse events involving the thyroid gland using immunoprecipitation and western blot analysis.

Complement- and inflammasome-mediated autoinflammation-paroxysmal nocturnal hemoglobinuria

This study identifies AIF-PNH as a disease caused by germline and somatic mutations in PIGT, leading to complement activation and inflammasome-mediated IL-1β secretion, which is treatable with eculizumab.

High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction

The paper shows that high STING expression in hepatocytes reduces HBV susceptibility by inducing type III IFN and IL-6.