Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis
L. Tanner, A. B. Single, R. K. V. Bonghir, R. Oomen, O. Wallner, T. Helleday, C. Kalderen, A. Egesten
This study shows that the small-molecule OGG1 inhibitor TH5487 reduces fibrosis and inflammation in a mouse model of pulmonary fibrosis.
bioRxiv · Feb 27, 2021 · PreprintPharmacology & Toxicology