Author

A. Egesten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

L. Tanner· 3 shared C. Kalderen· 2 shared J. Bergwik· 2 shared T. Helleday· 2 shared A. B. Single· 1 shared C. Dong· 1 shared I. Boldogh· 1 shared L. Pan· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersPharmacology & Toxicology

L. Tanner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

L. Tanner, J. Bergwik, R. K. Bhongir, L. Pan, C. Dong, C. Kalderen, T. Helleday, I. Boldogh, M. Adner, A. Egesten

This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.

bioRxiv · May 17, 2022 · PreprintPharmacology & Toxicology

Zoledronic acid targets the mevalonate pathway causing reduced cell recruitment and attenuation of pulmonary fibrosis

L. Tanner, J. Bergwik, R. K. V. Bhongir, A. Egesten

This study shows zoledronic acid reduces pulmonary fibrosis by targeting the mevalonate pathway, decreasing myofibroblast transition and immune cell recruitment in a mouse model.

bioRxiv · Dec 1, 2021 · PreprintPharmacology & Toxicology

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis

L. Tanner, A. B. Single, R. K. V. Bonghir, R. Oomen, O. Wallner, T. Helleday, C. Kalderen, A. Egesten

This study shows that the small-molecule OGG1 inhibitor TH5487 reduces fibrosis and inflammation in a mouse model of pulmonary fibrosis.

bioRxiv · Feb 27, 2021 · PreprintPharmacology & Toxicology