Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation
R. M. Jansen, R. Peruzzo, S. A. Fromm, A. L. Yokom, R. Zoncu, J. H. Hurley
The paper determines the cryo-EM structure of the active FLCN complex, revealing how it selectively regulates mTORC1 substrates TFEB and TFE3.
bioRxiv · Jun 28, 2022 · PreprintBiochemistry