Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of human IgG1 inhibitors of influenza B viruses
P. A. Blundell, D. Lu, A. Dell, S. Haslam, R. Pleass
The paper compares glycosylation differences in IgG1-Fc mutants produced in HEK 293-F and CHO-K1 cells, showing cell line effects on sialylation and receptor interactions.
bioRxiv · Jul 30, 2019Immunology