D. Lu

Dissecting cell-free DNA fragmentation variation in tumors using cell line-derived xenograft mouse

The paper investigates cfDNA fragmentation patterns in tumor models to distinguish between non-tumor cfDNA and ctDNA, finding differences in fragment length and site-specific variation.

The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

Simultaneous detection of pathogens and antimicrobial resistance genes with the open source, cloud-based, CZ ID pipeline

The paper develops an open-source, cloud-based tool for detecting pathogens and antimicrobial resistance genes in metagenomic and whole-genome sequencing data, demonstrating its application across clinical and environmental studies.

Development of a First-in-Class RIPK1 Degrader to Enhance Antitumor Immunity

This paper develops a first-in-class RIPK1 degrader, LD4172, which enhances antitumor immunity by promoting immunogenic cell death and sensitizing tumors to anti-PD1 therapy.

A conserved ion channel function of STING mediates non-canonical autophagy and cell death

This study identifies STING's ion channel function as critical for non-canonical autophagy and cell death via vesicle de-acidification.

Quantification of glutathione with high throughput live-cell imaging

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts

This study shows that KDM5C, an X-linked demethylase, promotes energy metabolism in osteoclasts to regulate female bone mass, offering a new target for osteoporosis treatment in women.

SREBP1 activation contributes to fatty acid accumulations in necroptosis

This study shows SREBP1 activation leads to VLCFA accumulation, which worsens necroptosis by increasing membrane permeabilization.

The role and mechanism of NRF2 in endothelial cells and smooth muscle cells of pulmonary artery

The paper investigates NRF2's role in pulmonary artery endothelial and smooth muscle cells under hypoxia, finding differential regulation and effects on proliferation and migration.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

MEK inhibitor resistance in lung cancer cells associated with addiction to sustained ERK suppression

The paper identifies drug addiction to MEK inhibitors in KRAS-mutant lung cancer cells, showing that resistance is linked to ERK suppression and KRAS amplification, suggesting therapeutic strategies involving drug holidays.

Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes

The paper introduces a method to identify phase-preference of molecules in live cell membranes using heptanol-mediated phase separation, enabling routine microscopy analysis of domain-localized molecules.

Remodeling of ryanodine receptor isoform 1 channel regulates the sweet and umami perception of Rattus norvegicus

The paper identifies RYR1 as a key channel regulating sweet and umami perception in rats through Ca2+ dynamics and proposes a metabolic clock model.

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

Hydroxide ions amplified by water entanglement underly the mechanism of general anesthesia

This study shows that inhaled anesthetics reduce neural excitability by disrupting multiple-water entanglement networks, which amplify hydroxide ion concentration changes.

Comparative analysis of temporal transcriptome reveals the relationship between pectin degradation and pathogenicity of defoliating Verticillium dahliae to Upland cotton (Gossypium hirsutum)

This study compares the temporal transcriptomes of two Verticillium dahliae strains to identify pectin degradation genes linked to pathogenicity in Upland cotton.

SIRT1 ameliorates premature senescence-induced defenestration in hepatic sinusoidal endothelial cell

This study shows that SIRT1 reduces premature senescence-induced defenestration in hepatic sinusoidal endothelial cells by deacetylating p53 and mitigating oxidative damage.

LZTR1 inactivation promotes MAPK/ ERK pathway activation in glioblastoma by stabilizing oncoprotein RIT1

This study shows that LZTR1 inactivation in glioblastoma stabilizes RIT1, leading to MAPK/ERK pathway activation and promoting tumor growth.

Enhancing Intracellular Accumulation and Target Engagement of PROTACs with Reversible Covalent Chemistry

This study discovers that reversible covalent chemistry enhances PROTAC intracellular accumulation and target engagement, leading to improved efficacy.

An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias

The paper develops a QSP model to predict drug-induced myelosuppression across multiple hematopoietic lineages and validates it with known drug mechanisms.

Choice of host cell line is essential for the functional glycosylation of the fragment crystallizable (Fc) region of human IgG1 inhibitors of influenza B viruses

The paper compares glycosylation differences in IgG1-Fc mutants produced in HEK 293-F and CHO-K1 cells, showing cell line effects on sialylation and receptor interactions.